Things didn't get any better for the home team in the third quarter. On thirdand9, Smith threw 30 yards to Crabtree, who evaded a host of tacklers. Then on thirdand8, Smith tossed a short pass to Moss, who sidestepped a series of wouldbe defenders all the way to the end zone, putting San Francisco ahead 240 with 7:27 left in the third quarter..We showed previously that TBS containing peptides interfere with normal tubulin dynamics.20 To investigate the effects of internalized NFLTBS.4063 further, we treated cultured cells with peptide or vehicle alone and evaluated intracellular tubulin distribution, cell shape, migration, and viability in vitro. While F98 and 9L cells, either untreated or treated with vehicle alone, were large, flat, and filled with a dense network of microtubules, cells that internalized detectable levels of NFLTBS.4063 typically became spherical, lost their pronounced microtubule network, and developed large aggregates (Figure 1a). As previously shown, some of t